How can syphilis enter the human body?

Syphilis is primarily transmitted through direct contact with syphilis sores, which are often found in the genital area, anus, or mouth. The genito-urinary tract is particularly significant because it includes not only the genital organs but also the urethra, which can serve as an entry point for the Treponema pallidum bacterium that causes syphilis.

While other routes such as skin breaches can theoretically allow for infection, they are less common in terms of transmission vectors for this specific disease. The respiratory and digestive tracts play minimal roles in syphilis transmission. Therefore, focusing on the genito-urinary tract accurately reflects the typical and most effective pathway for syphilis to enter the human body, aligning with the understanding of how sexually transmitted infections are spread.